oral diabetic medication.


According to researchers from the University of British Columbia (UBC), insulin from the most recent iteration of their oral tablets is absorbed by rats in a manner similar to that of insulin administered intravenously. The journal Scientific Reports also published the study's preliminary results.

The University of British Columbia (UBC) revealed the discovery in a press release, stating that "researchers have found that insulin from the newest version of their oral tablets is absorbed by rats in the same way as injected insulin."


Dr. Anubhav Pratap-Singh
Dr. Anubhav Pratap-Singh

Dr. Anubhav Pratap-Singh, an Indo-Canadian lead investigator and professor of land and food systems at UBC, is in charge of the study group.

The journal Scientific Reports also published the study's preliminary findings.

"These exciting results show that we are on the right track in developing an insulin formulation that will no longer need to be injected before every meal, improving the quality of life and mental health of more than nine million Type 1 diabetics worldwide," said Dr. Pratap-Singh, who studied chemical engineering at IIT-Kharagpur.

His father, a diabetic who has needed three or four insulin injections every day for the past 15 years, served as the research's motivation, he claimed.


Product process

A timeline for the finished product has not yet been established because the pill's research work has not yet advanced to human trials. But if effectively administered, the oral pill would "be more sustainable, cost-effective, and accessible," according to Dr. Pratap-Singh.

The UBC team concentrated on "how to promote a faster absorption rate" despite the fact that other oral insulin substitutes are being investigated all around the world.

This particular tablet is not meant to be swallowed but instead placed between the gum and cheek, allowing it to dissolve. “This method makes use of the thin membrane found within the lining of the inner cheek and back of the lips (also known as the buccal mucosa). It delivered all the insulin to the liver without wasting or decomposing any insulin along the way,” the UBC release stated.

The majority of the insulin from earlier attempts to create a drinkable form of insulin would accumulate in the stomach, according to Dr. Alberto Baldelli, a senior fellow in Dr. Pratap-lab. Singh's Now, he said, they are seeing nearly 100% of the insulin from their tablets go straight into the liver. According to Dr. Baldelli, "our oral administration tablet absorbs after half an hour and can last for roughly two to four hours long." rapid-acting insulin injection.

As their "oral alternative might be cheaper and easier to create," Dr. Pratap-Singh believed that their procedure will "lower the cost of insulin per dosage".

Source: Hindustan Times